Vascular Inflammation, Therapeutics & Analytics Lab

At VITAL, we strive to drive innovative research in vascular health and therapeutics, offering insights that lead to better patient outcomes.

Dr.Siddarth Raajasekar.,M.Sc., MS., Ph.D

Principal Investigator

Dr. Siddarth Raajasekar is a biochemist and Assistant Professor whose work focuses on vascular inflammation, immune-redox mechanisms, and translational biomarker research. He completed his PhD at the University of Canterbury, New Zealand, where he investigated macrophage activation and inflammatory metabolites in cardiovascular disease. His current research integrates clinical data analytics, computational drug discovery, and molecular modelling to study neurovascular dysfunction, antimicrobial resistance, and inflammasome-driven disease pathways. He leads the VITAL Lab and supervises biotechnology student teams working on high-impact computational and clinical projects, while actively collaborating with clinicians to develop next-generation diagnostics and therapeutic strategies.

Our Research Focus

Vascular Inflammation

Drug Discovery

Clinical Biomarkers

We specialize in understanding the mechanisms of vascular inflammation to develop therapeutic strategies.

Our computational approaches enhance drug discovery processes, bridging the gap between research and clinical applications.

Identifying and validating clinical biomarkers is crucial for advancing diagnosis and treatment in cardiovascular diseases.

Translational Biomedicine

We focus on translating basic scientific discoveries into real-world medical solutions that improve patient care.

Current Research Projects

The VITAL Lab is currently engaged in a diverse portfolio of computational and clinical research focused on vascular inflammation, neurovascular physiology, and therapeutic discovery. Our ongoing work includes analysing the GE-75 cohort to understand how systemic inflammation, metabolic stress, and microvascular injury influence cerebrovascular perfusion, vasoreactivity, cognition, and gait in individuals with Type 2 Diabetes. In parallel, we are investigating antimicrobial resistance patterns in uncomplicated urinary tract infections using the AMR-UTI PhysioNet dataset to identify predictors of treatment failure and empirical antibiotic inappropriateness. On the computational therapeutics front, the lab is conducting structure-guided drug repurposing studies targeting the NLRP3 inflammasome, mapping the binding behaviour of inhibitors such as MCC950 and OLT1177 across multiple conformational states, and identifying novel targets within glioma stem cell survival pathways for potential GBM therapeutics. Together, these projects reflect the lab’s commitment to bridging biotechnology, clinical analytics, and computational discovery to address critical challenges in vascular and inflammatory diseases.

Our Team.

Welcome to the VITAL Lab, where a passionate team of B.Tech Biotechnology students fuels our innovative projects. With expertise in vascular inflammation, computational drug discovery, and clinical dataset analytics, our collaborative environment thrives on curiosity and strong scientific foundations. Our students are integral to every aspect of our research, from data analysis and literature exploration to molecular modelling and manuscript preparation, propelling our lab's mission forward. Join us as we explore the frontiers of biotechnology!